What is Profound treatment?
Profound is a minimally invasive bipolar RF system with patented Real Time Temperature Control that
utilizes 5 pairs of micro-needle electrodes, deployed into the dermis, to precisely deliver fractionated
thermal injuries in the deep reticular dermis, where the concentration of collagen is the highest.
Fractionated thermal zones are created within the dermis, without thermal impact to the epidermis.
Thermal injury to treated areas stimulates would healing, dermal remodeling and new elastin, collagen,
and hyaluronic acid formation, resulting in visible skin improvement.
What is the effect of temperature on the dermal remodeling process?
To be effective, non-surgical skin rejuvenation procedures need to trigger the dermal remodeling process,
so that a global wound healing response is triggered and new elastin and collagen will proliferate.
Loss of elastin and collagen due to genetics and aging results in skin laxity and loss of elasticity. It
is known from the literature that partially denaturizing collagen is much more effective at triggering
neocollagenesis than fully denatured collagen.1,2 Partially denatured collagen can heal 38% faster than
fully denatured collagen and produces a more profound wound healing response. Dosimetry studies
have shown that to consistently produce partially denatured collagen, it is important to reach and
maintain a target dermal temperature at an optimal range of 67°C – 74°C for 3-4 seconds. Only with
Profound is it possible to accurately reach and maintain the exact thermal dose of energy (temperature
and time at temperature) needed to partially denature collagen and create the fastest healing response
for dermal remodeling.
Why is Profound a unique, novel device for treating skin laxity and increasing dermal volume, particularly of the jawline and submental area?
The Profound system incorporates temperature sensors embedded within the micro-needles and a realtime
temperature feedback algorithm to reach and maintain an optical dermal temperature of 67°C for
3-4 seconds, regardless of skin impedance or thermal conditions. Only Profound’s temperature-based
feedback algorithm can predictably meet the desired thermal endpoint. With this unique approach, a
vigorous wound healing response is initiated with a profound increase in elastin and collagen observed
at 10 weeks after treatment; thereby, resulting in greater clinical efficacy for rhytid and skin laxity
What can patients expect from Profound treatment?
Ideally, skin rejuvenation treatment should result in good aesthetic outcome with minimal risk of
complications. Neoelastogenesis and neocollagenesis should be clinically correlated with less skin
laxity, greater elasticity and increased dermal volume. Profound was developed to improve the efficacy
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www.syneron-candela.com and predictability of nonsurgical treatments. Studies have shown that a single Profound treatment has a 100% response rate for rhytides and 95% for laxity at 6 months after treatment*. Patients can return to normal activities within 24 hours after treatment. Minimal to moderate erythema is to be expected with resolution within 2-12 hours. Generalized edema may occur following treatment, which resolves within 1 to 5 days. Profound treatment is associated with minimal downtime compared to surgical face lift in which patients experience scarring at surgical margins, erythema, edema, and ecchymosis, and a return to normal activities on suture removal at 7 to 10 days.
What are the indications for Profound treatment?
Profound is indicated for use in dermatologic and general surgical procedures for electrocoagulation
and hemostasis, and the percutaneous treatment of facial wrinkles. The decision to treat with Profound
should be based upon appropriate diagnostic evaluation and consideration of all patient factors.
What types of treatments can be performed with Profound?
Profound can be used to treat nasolabial and melolabial folds, jowls, submental, submandibular
redundancy and neck strands by repairing the dynamic properties of the skin, elastin, collagen and
hyaluronic acid, and restoring dermal volume loss.
What percentage of your patients will respond to treatment?
Profound treatment has a 100% response rate for rhytides and 95% for laxity at 6 months after